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RU-21 (40 tablets) - the completely natural way to regulate alcohol metabolism
Tried & tested with full success – as seen on ITV's Richard & Judy programme, 16th Feb. 2004.
Buy Two Get Second One Half Price
Buy this special double pack of RU-21 (40 tablets) and you get
the second 20 tablet pack half price!
RU-21 is an all-natural supplement that has been clinically proven to regulate
alcohol metabolism in order to prevent alcohol-related damage to the vital organs
of the body. RU-21 was developed by the scientists at the Russian Academy of
Sciences in the course of a 25 year-long research project studying alcohol metabolism.
How it Works
When alcohol is consumed, it enters cells and is broken down into acetaldehyde.
Acetaldehyde is an extremely toxic compound believed to be responsible for both,
most alcohol-related diseases and the addictive process itself. The reaction is
as follows: CH3CH2OH+NAD+® CH3CHO+NADN+H+ (1)
Then an enzyme called aldehyde dehydrogenise 2 (ALDH2) converts the acetaldehyde into acetic acid, which is non-toxic and can be readily used by the body to provide energy, eventually breaking down into water and carbon dioxide. However, the body is only able to metabolize a certain amount of acetaldehyde within a certain period of time regardless of how much alcohol is being consumed. Consequently, alcohol consumption often results in excess acetaldehyde entering blood stream and causing severe damage to the vital organs and functions of the body.
RU-21 balances alcohol metabolism by slowing down the process of ethanol oxidation into acetaldehyde, so less acetaldehyde occurs in the first place, and then speeding up the process of acetaldehyde decomposition into acetic acid and then water and carbon dioxide.
The first task – slowing down ethanol oxidation into acetaldehyde was accomplished by the inclusion of dextrose (glucose) into the formula. Dextrose rapidly oxidizes in cytosol of liver cells using the same cytosol NAD pool used by ethanol to convert into acetaldehyde, thereby creating a deficit of cytosol NAD needed for the reaction (1) shown above.
Further, the acceleration of decomposition of acetaldehyde and acetic acid into CO2 and H2O and the energizing of mitochondria were accomplished through activation of aerobic oxidation processes in mitochondria by way of introducing substrates (Succinic Acid, Fumaric Acid), which activate the second half-cycle of tricarboxylic acids. Succinate substrate, which is independent of NADN-dehydrogenise prevents acetaldehyde from causing hypoxia, which often results form the accumulation of suboxidized metabolites, and from impeding NADN oxidation in the respiratory chain of cells.
L-Glutamine was added to the formula to speed up the mitochondria-cytosolic malate-aspartate shuttle, which plays key role in the course of acetaldehyde intoxication development. It also speeds up succinate oxidation process (by preventing oxalic and acetic inhibition of succinate dehydrogenase). In addition, it transforms itself into a-ketoglutarate during a rapid oxidation in Crebs cycle. And finally, the proper concentration of L-Glutamine positively influences glutamate and GAMC synapses in the brain, improving coordination and inhibition processes affected by alcohol intoxication.
Ascorbic Acid was added to the formula in order to activate anti-oxidant systems of the central nervous system, liver and hormone-active tissues (affected by hypoxia and acetaldehyde) and to support adrenal gland cortex, which produces anti-stress hormones.
RU-21 is manufacture and marketed by Spirit Sciences USA, Inc. a California-based company engaged in the discovery, development, manufacture and marketing of breakthrough pharmaceutical and nutritional products.
The company employs over 1,000 people and markets its products in 15 countries in Europe, North America and countries of CIS.
Clinical Trials
Clinical trials were conducted at the Russian Academy of Sciences, Ministry
of Public Health of RF, and earlier at laboratory of the Soviet Military Academy
of Sciences.
The analysis of scientific data obtained from those clinical trials proved that 1,0g to 3,0g of RU-21 (0,5g tablets) introduced before or during alcohol consumption, significantly reduces the risk of alcohol-related diseases as well as mutagenesis (damage to DNA cells) and also prevents alcohol-induced hangover.
Questions & Answers
Q: When should I use RU-21?
A: It is a good idea to always use RU-21 when consuming alcohol. Using RU-21
with even minimal amounts of alcohol will help maintain good health and even appearance,
since acetaldehyde is also known to cause premature aging of skin.
Q: How should I use RU-21?
A: For best results RU-21 should be taken prior or during alcohol consumption.
Q: How many tablets should I take?
A: Normally, one-two tablets before and one-two tablets during alcohol
consumption, depending on body weight, amount of alcohol consumed and whether
or not any food is being consumed. However, taking up to 6 tablets will not
result in any undesired side-effects and many people choose to do so if they’re
especially susceptible to hangovers.
Q: Will RU-21 prevent intoxication?
A: No, it will not.
Q: What sets RU-21 apart from competition?
A: There is presently no known direct competition.
Published Testimonials About Ru-21
The following testimonials from journalists were published in the Rocky
Mountain News.
Rocky Mountain News – Testing the claims
September 2, 2003 When we heard about RU-21 - a proclaimed
hangover cure - we decided to put it to the test. Volunteers from the newsroom
conducted their experiments at home or with designated drivers. Here's what
they had to say:
"I couldn't convince myself to pursue a heavy-duty hangover, not even in the
spirit of work duty and scientific experimentation. But having five or six beers
in an evening can leave me with a mild headache the next morning, so I figured
I could endure that much discomfort for the greater good. On night one, I had
five 12-ounce beers during and after dinner; the low-grade headache arrived
on schedule in the morning. On night two, I had a comparable meal and the same
five beers, this time taking one two-tablet dose of RU-21 as I cracked open
the first, third and fifth brews. Come morning, the headache was conspicuously
- and welcomely - absent."
Jay Dedrick, 37
"After ingesting one RU-21 tablet after every two drinks (the instructions
are confusing; I later noticed it's one serving - or two pills - for every two
drinks), I woke up the next morning feeling fine, if not downright chipper.
I admit, as a trained professional, I'm not prone to hangovers. But when I do
get one, I get it with a vengeance - headache, nausea, lethargy. But with the
help of RU-21, I felt like playing at least 18 holes of golf. Too bad I had
to work. The bartender who assisted us in our experiment wants me to report
back to him on the results. I'm saying yea, not nay, to RU-21."
Penny Parker, 49
"I thought I would put this stuff to the test by drinking microbrews, something
I enjoy occasionally that can leave a mark on me if I have more than three.
The first night, I drank five in about two hours - without the aid of the pills.
I woke up the next morning with a light but noticeable headache and felt sluggish
until about noon. The next night, I tried the pills. Their aftertaste was citrusy
but complemented the beer nicely. I had the same five brews, then threw one
more down for good measure. I woke up the next morning without any of the nagging
aches or usual hangover effects. I was still slightly drowsy, but since the
supplement doesn't claim to prevent that, I'll cut it some slack." Brian James, 30
Buy Two Get Second One Half Price
Buy this special double pack of RU-21 (40 tablets) and you get the
second 20 tablet pack half price!
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